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Buy Nolvadex Online

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Active Ingredient: Tamoxifen

Nolvadex – An antitumor drug. Antiestrogen. It blocks estrogen receptors and thus inhibits the progression of a tumor disease stimulated by estrogen.

All you need to know about Nolvadex

In the world, Nolvadex is recognized as the safest and most effective drug that affects estrogen receptors.

The drug is used for the prevention and treatment of malignant breast tumors, Albright syndrome. As an antiestrogen, Nolvadex helps cure these diseases.

Instructions for use

Before you start a therapeutic course using Nolvadex tablets, you must read the instructions for use. It contains important information about the features of taking the medicine, interacting with other medicines, and possible unwanted reactions. Failure to comply with the recommendations prescribed in the instructions may lead to inefficiency of the drug.

Pharmacological group

Nolvadex belongs to antitumor drugs and acts as an antagonist of hormones (antiestrogen).

Pharmacodynamics

The active substance is similar to estrogen and has the property of binding to receptors in target organs. Tamoxifen enters the nucleus of the tumor, stops the action of the steroid female hormone and thereby inhibits the development of malignant tumors. After a single application, another 2 to 3 weeks is able to maintain the function of blocking estrogen.

Pharmacokinetics

The pharmaceutical agent is well absorbed in the gastrointestinal tract. The absorption period ranges from 4-7 hours. 99% of the active substance binds to plasma proteins.

Nolvadex is metabolized in the liver (hydroxylation and demethylation reactions), excreted primarily with bile. Withdrawal is divided into two phases: T1 and T2.

The first ends within 13 hours after admission, the second a week later. A small part of the drug is excreted in the urine.

Information on the main active substance

The main component of the antiestrogen is tamoxifen. It is a white powder, sparingly soluble in water. It is divorced by organic solvents. The substance acts on the body and is metabolized in the liver by the isoform of cytochrome P450 CYP2D6 and CYP3A4 into active metabolites.

Indications for use:

Nolvadex is effective against the following diseases:

  • breast cancer (BC), kidney, endometrium,
  • oligospermia,
  • Albright’s syndrome.

Contraindications

Before prescribing Nolvadex, the doctor rules out pregnancy because the pills can affect the development of the embryo. It is not recommended to take an antiestrogen during breastfeeding.

Contraindications to the appointment of anticancer tablets are also:

  • individual intolerance to the active substance,
  • cataract development
  • thrombophlebitis
  • leukopenia and thrombocytopenia.

Today, clinical trials of drugs as a means for the treatment of other forms of cancer and estrogen-dependent diseases are underway.

How to use and dosage methods

Dosage depends on the type of disease. With breast cancer, endometrium, and kidneys, 20–40 mg is prescribed orally twice a day (morning and evening), and administration continues until positive dynamics appear. The course is 2.4 – 9.6 g.

If a woman does not become pregnant due to anovulation: on the second day after the onset of menstruation, 4 mg 2 times a day should be taken 10 mg of the drug. Under the supervision of a doctor, the dose may increase to 20 and even up to 40 mg.

  • With reduced sperm excretion during ejaculation, the therapeutic dose is 10 mg per day.
  • The peculiarity of the reception is that you need to drink the tablet without chewing with a small amount of still water.
  • The drug is prescribed strictly under the supervision of an oncologist or mammologist.

Carefully

For children, the dosage is 20 mg 1 time per day. This dose has been clinically tested on 28 girls. During therapy, an increase in the uterus was recorded. No more studies on children have been conducted.

Side effects

Nolvadex is a fairly strong drug, so after taking it, a number of side effects may appear:

  • increased risk of thrombophlebitis;
  • increased liver enzymes;
  • stroke;
  • pulmonary embolism;
  • vision problems;
  • weight loss;
  • nausea, vomiting;
  • headaches;
  • intermenstrual bleeding;
  • confusion of consciousness;
  • depressive disorders;
  • violation of the functional functioning of the liver (with a long course);
  • osteoporosis;
  • obstructive jaundice (due to the formation of stones in the gall bladder with prolonged therapy);
  • decrease in the number of active sperm;
  • a malignant tumor developing from the uterine epithelium (an isolated case).

Compared to other antiestrogens, Nolvadex has minor complications, most of which do not manifest under the supervision of a physician.

Alcohol compatibility

It is strictly forbidden to take alcoholic beverages in severe diseases associated with the cardiovascular and other systems. In men, because of the increased production of testosterone, the liver works more actively. It is affected not only by sex hormone, but also by the drug itself.

Alcohol can cause a worsening of the pathological process, the emergence of new side effects that should not be observed after taking antiestrogen tablets.

Special instructions

Patients who take an antitumor medication should be under the close attention of a gynecologist. With the development of bleeding, the reception should be stopped. The same situation is with the appearance of blood clots in the vessels of the lower extremities.

Price and where to buy Nolvadex

30 tab. 10 MG5.00$
30 tab. 20 MG10.00$
60 tab. 20 MG15.00$

The active compound in Nolvadex (Nolvadex) is Tamoxifen (Tamoxifen). This substance belongs to the group of antitumor agents with anti-hormonal activity. Its use is indicated in the treatment of various forms of malignant breast tumors in both men and women, as well as in the treatment of endometrial cancer.

Remember that with us you can buy Nolvadex (Tamoxifen) absolutely safely and at a bargain price.